E-Cadherin antibody [36B5]

Cannot supply to this region.

SKU:: GTX01965
Additional Names:: cadherin 1 , Arc-1 , BCDS1 , CD324 , CDHE , ECAD , LCAM , UVO
Application:: IHC-P
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Unpurified
Storage Conditions:: 2-8[o]C Do not freeze.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: Tissue culture supernatant, 0.09% Sodium azide.
Immunogen:: Prokaryotic recombinant protein corresponding to the N-terminal external region of the E-Cadherin molecule.
Clone:: 36B5
Uniprot:: P12830
Synonyms:: Arc-1;BCDS1;cadherin 1, E-cadherin (epithelial);cadherin 1, type 1, E-cadherin (epithelial);cadherin-1;calcium-dependent adhesion protein, epithelial;CAM 120/80;CD324;CDHE;cell-CAM 120/80;E-cadherin 1;ECAD;epididymis secretory sperm binding protein;epithelial cadherin;LCAM;UVO;uvomorulin
Extra Details:: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Shipping Conditions:: Blue Ice