Langerin antibody [12D6]

Cannot supply to this region.

SKU:: GTX01915
Additional Names:: CD207 molecule , CLEC4K
Application:: IHC-P
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Unpurified
Storage Conditions:: 2-8[o]C Do not freeze.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: Tissue culture supernatant, 0.09% Sodium azide.
Immunogen:: Prokaryotic recombinant protein of 29 kD corresponding to the external domain of the langerin molecule.
Clone:: 12D6
Uniprot:: Q9UJ71
Synonyms:: C-type lectin domain family 4 member K;C-type lectin domain family 4, member K;CD207 antigen, langerin;CD207 molecule, langerin;CLEC4K;Langerhans cell specific c-type lectin;Langerin
Extra Details:: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]