MLKL antibody [GT1191]

Cannot supply to this region.

SKU:: GTX00953
Additional Names:: mixed lineage kinase domain like pseudokinase , MLKL , hMLKL , mixed lineage kinase domain like
Application:: WB
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: A synthesized peptide derived from human MLKL.
Clone:: GT1191
Uniprot:: Q8NB16
Synonyms:: hMLKL;mixed lineage kinase domain-like protein
Extra Details:: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]