GTX00483-08
CD35 antibody [E11] (PE)
Cannot supply to this region.
- SKU:
- GTX00483-08
- Additional Names:
- C3BR , C4BR , CD35 , CR1 , KN , complement C3b/C4b receptor 1 (Knops blood group)
- Application:
- Flow Cytometry
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Size-exclusion Chromatography
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS, 15mM Sodium azide.
- Immunogen:
- Acute monocytic leukemia cells and normal blood monocytes
- Clone:
- E11
- Uniprot:
- P17927
- Synonyms:
- C3-binding protein;C3b/C4b receptor;C3BR;C4BR;CD35;CD35 antigen;complement component (3b/4b) receptor 1 (Knops blood group);complement receptor 1;complement receptor type 1;KN;Knops blood group antigen
- Extra Details:
- This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice