Human CNTF Protein

Size

£497.00

SKU:: PME30084
Additional Names:: Ciliary Neurotrophic Factor;CNTF
Molecular Weight:: 22.93 KDa
Purity:: Greater than 95% as determined by reducing SDS-PAGE.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl; 100mM NaCl; pH 8.0.
Target:: CNTF
Not available:: Not available
Extra Details:: Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6; IL11; LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF; like FGF acidic; FGF basic; and PD-ECGF (platelet-derived endothelial cell growth factor); does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.