PME30082
Human CCL23 Protein
Size
£497.00
- SKU:
- PME30082
- Additional Names:
- C-C Motif Chemokine 23;CK-Beta-8;CKB-8;Macrophage Inflammatory Protein 3;MIP-3;Myeloid Progenitor Inhibitory Factor 1;MPIF-1;Small-Inducible Cytokine A23;CCL23;MIP3;MPIF1;SCYA23
- Molecular Weight:
- 8.7 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from a 0.2 μm filtered solution of 20mM PB; 250mM NaCl; pH 7.2.
- Target:
- CCL23
- Not available:
- Not available
- Extra Details:
- Human Chemokine (C-C Motif) Ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family. CCL23 is also known as myeloid progenitor inhibitory factor MPIF-1; CK8 and SCYA23. CCL23 cDNA encodes a 120 amino acid residue precursor protein with a putative 21 amino acid residue signal peptide that is cleaved to generate a 99 amino acid residue mature CCL23 (amino acids 22 -120). Additional N-terminal Processing of the 99 amino acid residue variant can generate a 75 amino acid residue peptide (amino acid 46-120) that is significantly more active than the 99 amino acid residue variant. CCL23 binds to CCR1 with high affinity and has chemotactic activity for monocytes; dendritic cells; and osteoclast precursors. CCL23 enhances angiogenesis of endothelial cells; but reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages.
- Shipping Conditions:
- Ambient