Human IL-28A (C-6His) Protein

Size

£457.00

SKU:: PME30074
Additional Names:: Interferon lambda-2;IFN-lambda-2;Cytokine Zcyto20;Interleukin-28A;IL-28A;IFNL2;IL28A;ZCYTO20
Molecular Weight:: 20.6 KDa
Purity:: Greater than 95% as determined by reducing SDS-PAGE.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from a 0.2 μm filtered solution of PBS; pH 7.4.
Target:: IL-28A
Not available:: Not available
Extra Details:: IL-28A (Interferon-λ2? IFN-λ2); IL-28B/IFN-λ3; and IL-29/IFN-λ1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines. Mature human IL-28A is an approximately 22-25 kDa protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29; respectively. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. IL-28A additionally exhibits anti-tumor activity; in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast; it is up-regulated in invasive bladder cancer where it promotes tumor cell migration.