PME30041
Human SHH (C-6His) Protein
Size
£341.00
- SKU:
- PME30041
- Additional Names:
- Sonic Hedgehog Protein;SHH;HHG-1
- Molecular Weight:
- 20.4 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from a 0.2 μm filtered solution of PBS; pH 7.4.
- Target:
- SHH
- Not available:
- Not available
- Extra Details:
- Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems; such as limbs and brain. SHH also plays an important role in adult; including the division of adult stem cells and the development of certain cancers and other diseases. Human SHH is expressed as a 45kDa precursor; and undergoes a series of processing during secretion. After the removal of the signal peptide; a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N has the “all signaling” capability. SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface; which releases the repression of the activity of Smoothened (Smo); a G-protein coupled receptor; by Ptc.
- Shipping Conditions:
- Ambient