PME30030
Human Beta-NGF (Mammalian) Protein
Size
£202.00
- SKU:
- PME30030
- Additional Names:
- Beta-Nerve Growth Factor;Beta-NGF;NGF;NGFB;-NGF
- Molecular Weight:
- 13.3 KDa
- Purity:
- Greater than 95% as determined by reducing SDS-PAGE.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from a 0.2 μm filtered solution of 20mM PB; 250mM NaCl; pH 7.0.
- Target:
- Beta-NGF
- Not available:
- Not available
- Extra Details:
- Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits a; β; and γ; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF; NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF; and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine; which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90% sequence similarity with mouse protein and shows cross-species reactivity.
- Shipping Conditions:
- Ambient