Human GPR15 Protein; hFc Tag

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£194.00

SKU:: PME101931
Additional Names:: GPR15; BOB; G protein-coupled receptor 15; HPT-3-2
Molecular Weight:: The protein has a predicted molecular mass of 30.0 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: GPR15
GPR15(Met1-Ser33) hFc(Glu99-Ala330):: GPR15(Met1-Ser33) hFc(Glu99-Ala330)
Extra Details:: GPR15 (G protein-coupled receptor 15 / BOB) is a G-protein coupled receptor (GPCR) expressed in T cells; colon; and vascular endothelium. It primarily couples to Gi/o proteins; modulating cAMP levels and intracellular signaling pathways. GPR15 functions as a lymphocyte homing receptor; directing T cell migration to the colon and mucosal tissues; and is implicated in immune regulation; inflammation; and HIV/SIV entry. Dysregulation of GPR15 is associated with autoimmune and inflammatory diseases; making it a potential therapeutic target in immunology.

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