Human HRH1 Protein; hFc Tag

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£189.00

SKU:: PME101921
Additional Names:: H1R; Histamine H1 receptor; Histamine receptor 1
Molecular Weight:: The protein has a predicted molecular mass of 29.1 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: HRH1
HRH1(Met1-Leu27) hFc(Glu99-Ala330):: HRH1(Met1-Leu27) hFc(Glu99-Ala330)
Extra Details:: HRH1 (Histamine receptor H1) is a G-protein coupled receptor (GPCR) that primarily couples to Gq/11 proteins; activating phospholipase C (PLC); increasing IP₃/DAG levels and intracellular Ca²⁺ mobilization. HRH1 is expressed in smooth muscle; endothelial cells; brain; and immune cells; mediating allergic responses; vasodilation; bronchoconstriction; and neurotransmission. Dysregulation of HRH1 signaling is associated with allergies; asthma; inflammation; and CNS disorders; making it a therapeutic target for antihistamines and allergy treatments.

Shipping Conditions:: Ambient