Human HCAR2 Protein; hFc Tag

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£189.00

SKU:: PME101919
Additional Names:: GPR109A; NIACR1; HM74A; PUMA-G; Hydroxycarboxylic acid receptor 2
Molecular Weight:: The protein has a predicted molecular mass of 29.6 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: HCAR2
HCAR2(Met1-Lys28) hFc(Glu99-Ala330):: HCAR2(Met1-Lys28) hFc(Glu99-Ala330)
Extra Details:: HCAR2 (GPR109A / Hydroxycarboxylic acid receptor 2) is a G-protein coupled receptor (GPCR) primarily expressed in adipose tissue; immune cells; and colonic epithelium. It couples to Gi/o proteins; inhibiting adenylyl cyclase and reducing cAMP levels. HCAR2 mediates anti-lipolytic effects; regulation of inflammation; and immune cell modulation. Pharmacologically; it is the target of niacin and related compounds and is implicated in atherosclerosis; metabolic disorders; and immune regulation; making it a relevant therapeutic target in cardiovascular and metabolic diseases.

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