Human GPR183 Protein; hFc Tag

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£189.00

SKU:: PME101918
Additional Names:: EBI2; Epstein-Barr virus–induced G-protein coupled receptor 2; EBI2R
Molecular Weight:: The protein has a predicted molecular mass of 29.5 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: GPR183
GPR183(Met1-Arg31) hFc(Glu99-Ala330):: GPR183(Met1-Arg31) hFc(Glu99-Ala330)
Extra Details:: GPR183 (EBI2 / G protein-coupled receptor 183) is a G-protein coupled receptor (GPCR) primarily expressed in B cells; T cells; and dendritic cells. It couples to Gi proteins; inhibiting adenylyl cyclase and modulating intracellular cAMP. GPR183 regulates immune cell migration; positioning within lymphoid tissues; and adaptive immune responses. Dysregulation is implicated in autoimmune diseases; lymphoid malignancies; and chronic inflammation; making GPR183 a potential therapeutic target in immunology and oncology.