Human GPR143 Protein; hFc Tag

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£189.00

SKU:: PME101916
Additional Names:: OA1; Ocular albinism type 1 protein; Xp22.3-p22.2 GPR143
Molecular Weight:: The protein has a predicted molecular mass of 29.1 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: GPR143
GPR143(Met1-Arg27) hFc(Glu99-Ala330):: GPR143(Met1-Arg27) hFc(Glu99-Ala330)
Extra Details:: GPR143 (G protein-coupled receptor 143 / OA1) is an intracellular G-protein coupled receptor (GPCR) primarily expressed in melanosomes of retinal pigment epithelium and melanocytes. It regulates melanosome biogenesis; pigmentation; and intracellular signaling. Mutations in GPR143 cause ocular albinism type 1 (OA1); leading to hypopigmentation; vision defects; and foveal hypoplasia. GPR143 is a key target for research into pigmentation disorders and retinal development.