PME101913
Human IL6ST Protein; His Tag
Size
£194.00
- SKU:
- PME101913
- Additional Names:
- GP130; CD130; IL6Rβ; IL6 receptor subunit beta; IL6 signal transducer
- Molecular Weight:
- The protein has a predicted molecular mass of 69.2 kDa after removal of the signal peptide.
- Purity:
- The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- IL6ST
- IL6ST(Glu23-Glu619) 10×His tag:
- IL6ST(Glu23-Glu619) 10×His tag
- Extra Details:
- IL6ST (GP130 / Interleukin-6 signal transducer) is a transmembrane receptor subunit that mediates signaling of the IL-6 family cytokines; including IL-6; IL-11; LIF; and OSM. It forms heterodimeric or multimeric receptor complexes; activating JAK/STAT; MAPK; and PI3K/AKT pathways. IL6ST is widely expressed in immune cells; liver; heart; and other tissues; regulating inflammation; hematopoiesis; immune responses; and tissue regeneration. Dysregulation is associated with autoimmune diseases; chronic inflammation; and cancer; making it an important therapeutic target in cytokine-mediated disorders.
- Shipping Conditions:
- Ambient