Human FFAR3 Protein; hFc Tag

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£189.00

SKU:: PME101912
Additional Names:: FFAR3; GPR41; FFA3; Free fatty acid receptor 3; G-protein coupled receptor 41
Molecular Weight:: The protein has a predicted molecular mass of 27.9 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: FFAR3
FFAR3(Met1-Trp15) hFc(Glu99-Ala330):: FFAR3(Met1-Trp15) hFc(Glu99-Ala330)
Extra Details:: FFAR3 (Free fatty acid receptor 3 / GPR41) is a G-protein coupled receptor (GPCR) that binds short-chain fatty acids (SCFAs) such as acetate; propionate; and butyrate. It primarily couples to Gi/o proteins; inhibiting adenylyl cyclase and modulating cAMP levels. FFAR3 is expressed in adipose tissue; gut; and sympathetic neurons; where it regulates energy metabolism; insulin secretion; gut hormone release; and sympathetic nervous system activity. Dysregulation of FFAR3 signaling is implicated in metabolic disorders; obesity; and diabetes; making it a potential therapeutic target in metabolic and cardiovascular diseases.

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