PME101903
Human C3AR1 Protein; hFc Tag
Size
£189.00
- SKU:
- PME101903
- Additional Names:
- AZ3B; C3AR; C3R1; HNFAG09; C3a anaphylatoxin chemotactic receptor
- Molecular Weight:
- The protein has a predicted molecular mass of 28.7 kDa after removal of the signal peptide.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- C3AR1
- C3AR1(Met1-Val23) hFc(Glu99-Ala330):
- C3AR1(Met1-Val23) hFc(Glu99-Ala330)
- Extra Details:
- C3AR1 encodes the C3a receptor (C3aR1); a G-protein coupled receptor (GPCR) that binds the complement component C3a; a key anaphylatoxin in the immune system. C3AR1 couples primarily to Gi proteins; leading to inhibition of adenylyl cyclase; Ca²⁺ mobilization; and activation of MAPK and NF-κB signaling. It is expressed on immune cells including neutrophils; monocytes; macrophages; and mast cells; where it mediates chemotaxis; degranulation; cytokine release; and inflammatory responses. C3AR1 plays a critical role in innate immunity; inflammation; and host defense; and dysregulation is implicated in allergic diseases; sepsis; autoimmune disorders; and cancer.
- Shipping Conditions:
- Ambient