PME101900
Human RGR Protein; hFc Tag
Size
£189.00
- SKU:
- PME101900
- Additional Names:
- RGR‑opsin; RP44; Retinal G protein‑coupled receptor
- Molecular Weight:
- The protein has a predicted molecular mass of 27.7 kDa after removal of the signal peptide.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- RGR
- RGR(Met1-Glu15) hFc(Glu99-Ala330):
- RGR(Met1-Glu15) hFc(Glu99-Ala330)
- Extra Details:
- RGR encodes the retinal G protein-coupled receptor; a non-visual opsin belonging to the GPCR (G-protein coupled receptor) family. It is primarily expressed in the retinal pigment epithelium (RPE) and Müller glial cells. Unlike classical visual opsins; RGR binds all-trans-retinal instead of 11-cis-retinal and can photoisomerize it back to 11-cis-retinal upon light exposure; suggesting a role in the visual cycle regeneration of chromophore. RGR may function as a photoisomerase or light sensor; contributing to retinal pigment metabolism and photoreceptor maintenance. Mutations in RGR have been associated with retinitis pigmentosa and retinal degenerative disorders; highlighting its importance in retinal homeostasis and visual physiology.
- Shipping Conditions:
- Ambient