Human P2RY12 Protein; hFc Tag

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£189.00

SKU:: PME101899
Additional Names:: ADP‑glucose receptor (ADPG‑R); P2T(AC); P2Y12; HORK3; SP1999
Molecular Weight:: The protein has a predicted molecular mass of 29.1 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: P2RY12
P2RY12(Met1-Leu27) hFc(Glu99-Ala330):: P2RY12(Met1-Leu27) hFc(Glu99-Ala330)
Extra Details:: P2RY12 encodes the P2Y purinoceptor 12; a G-protein coupled receptor (GPCR) that primarily responds to adenosine diphosphate (ADP). It couples to Gi proteins; leading to inhibition of adenylyl cyclase and reduction of intracellular cAMP levels. P2RY12 is highly expressed on platelets; where it plays an essential role in platelet activation; aggregation; and thrombus formation. It is the pharmacological target of antiplatelet drugs such as clopidogrel; prasugrel; and ticagrelor. Beyond the circulatory system; P2RY12 is also expressed in microglia within the central nervous system; where it regulates microglial chemotaxis and homeostatic responses. Dysregulation of P2RY12 is implicated in thrombosis; stroke; and neuroinflammation.

Shipping Conditions:: Ambient