Human NTSR2 Protein; hFc Tag

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£189.00

SKU:: PME101895
Additional Names:: NT‑R‑2; NTR2
Molecular Weight:: The protein has a predicted molecular mass of 29.6 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: NTSR2
NTSR2(Met1-Lys32) hFc(Glu99-Ala330):: NTSR2(Met1-Lys32) hFc(Glu99-Ala330)
Extra Details:: NTSR2 encodes the neurotensin receptor type 2; a G-protein coupled receptor (GPCR) that binds the neuropeptide neurotensin (NTS). It primarily couples to Gq/11 and Gi/o proteins; triggering downstream phospholipase C activation; Ca²⁺ mobilization; and MAPK signaling. NTSR2 is expressed in the central nervous system (notably in the midbrain; hypothalamus; and spinal cord) as well as in peripheral tissues. It mediates neurotensin-induced analgesia; hypothermia; and regulation of dopamine transmission; and contributes to neuronal excitability; pain modulation; and neuroendocrine secretion. Altered NTSR2 expression has been linked to psychiatric disorders; neuroinflammation; and certain cancers; making it a potential therapeutic target in neurobiology and oncology.

Shipping Conditions:: Ambient