Human HTR6 Protein; hFc Tag

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£194.00

SKU:: PME101894
Additional Names:: 5-HT6; 5-HT6R
Molecular Weight:: The protein has a predicted molecular mass of 28.6 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: HTR6
HTR6(Met1-Gly27) hFc(Glu99-Ala330):: HTR6(Met1-Gly27) hFc(Glu99-Ala330)
Extra Details:: HTR6 encodes the 5-hydroxytryptamine (serotonin) receptor 6; a G-protein coupled receptor (GPCR) that primarily couples to Gs proteins; leading to activation of adenylyl cyclase and elevation of intracellular cAMP levels. It is mainly expressed in the central nervous system; particularly in the striatum; cortex; hippocampus; and olfactory tubercle; where it modulates cholinergic; dopaminergic; and glutamatergic neurotransmission. HTR6 plays important roles in cognition; learning; memory; and mood regulation. Dysregulation of HTR6 signaling has been implicated in Alzheimer’s disease; schizophrenia; and cognitive impairment; making it a potential therapeutic target for neuropsychiatric and neurodegenerative disorders.

Shipping Conditions:: Ambient