Human HTR2A Protein; hFc Tag

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£189.00

SKU:: PME101893
Additional Names:: 5-HT-2，5-HT-2A，Serotonin receptor 2A，HTR2A，HTR2
Molecular Weight:: The protein has a predicted molecular mass of 34.7 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: HTR2A
HTR2A(Met1-Trp76) hFc(Glu99-Ala330):: HTR2A(Met1-Trp76) hFc(Glu99-Ala330)
Extra Details:: HTR2A encodes the 5-hydroxytryptamine (serotonin) receptor 2A; a G-protein coupled receptor (GPCR) that mediates many of serotonin’s effects in the central nervous system and peripheral tissues. It primarily couples to Gq/11 proteins; activating the phospholipase C (PLC)–IP₃–Ca²⁺ signaling pathway; leading to neuronal excitation and modulation of neurotransmitter release. HTR2A is highly expressed in the cerebral cortex; hippocampus; and platelets; and regulates mood; perception; sleep; and cognition. Dysregulation or polymorphisms of HTR2A are associated with psychiatric disorders such as schizophrenia; depression; and anxiety; and it is a pharmacological target of antipsychotics; antidepressants; and hallucinogens (e.g.; LSD; psilocybin).

Shipping Conditions:: Ambient