Human PDGFB Protein; hFc Tag

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£199.00

SKU:: PME101871
Additional Names:: SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2
Molecular Weight:: The protein has a predicted molecular mass of 38.4 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: PDGFB
hFc(Glu99-Ala330) PDGFB(Ser82-Thr190):: hFc(Glu99-Ala330) PDGFB(Ser82-Thr190)
Extra Details:: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B; which can homodimerize; or alternatively; heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases; which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17; at sites where this gene and that for collagen type 1; alpha 1 are located; are associated with dermatofibrosarcoma protuberans; a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq; Oct 2015]

Shipping Conditions:: Ambient