Human ACKR2 Protein; hFc Tag

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£194.00

SKU:: PME101827
Additional Names:: D6; hD6; CCR9; CCBP2; CCR10; CMKBR9
Molecular Weight:: The protein has a predicted molecular mass of 31.3 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: ACKR2
ACKR2(Met1-Lys46) hFc(Glu99-Ala330):: ACKR2(Met1-Lys46) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a beta chemokine receptor; which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however; its specific function remains unknown. This gene is mapped to chromosome 3p21.3; a region that includes a cluster of chemokine receptor genes. [provided by RefSeq; Jul 2008]

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