Human CD117 (925-976) Protein; mFc Tag

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£184.00

SKU:: PME101771
Additional Names:: PBT; SCFR; C-Kit; KIT; MASTC
Molecular Weight:: The protein has a predicted molecular mass of 31.9 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: CD117
CD117(Glu925-Val976) mFc(Pro99-Lys330):: CD117(Glu925-Val976) mFc(Pro99-Lys330)
Extra Details:: This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains; a transmembrane region; and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand; stem cell factor (SCF); this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation; differentiation; migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis; stem cell maintenance; gametogenesis; melanogenesis; and in mast cell development; migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors; mast cell disease; acute myelogenous leukemia; and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq; May 2020]

Shipping Conditions:: Ambient