Human ACVR2B(67-87) Protein; mFc Tag

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£194.00

SKU:: PME101651
Additional Names:: HTX4; ACTRIIB; ActR-IIB
Molecular Weight:: The protein has a predicted molecular mass of 28.7 kDa after removal of the signal peptide. The apparent molecular mass of ACVR2B(67-87)-mFc is approximately 25-35 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: ACVR2B
ACVR2B(Ser67-Arg87) mFc(Pro99-Lys330):: ACVR2B(Ser67-Arg87) mFc(Pro99-Lys330)
Extra Details:: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor; which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq; Jul 2008]

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