Human ADAM17 Protein; hFc Tag

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£199.00

SKU:: PME101486
Additional Names:: CSVP; TACE; CD156B; NISBD1
Molecular Weight:: The protein has a predicted molecular mass of 100.2 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: ADAM17
ADAM17(Pro18-Asn671) hFc(Glu99-Ala330):: ADAM17(Pro18-Asn671) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins; and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions; including fertilization; muscle development; and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha; in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates; including cell adhesion proteins; cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands; and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis; rheumatoid arthritis; multiple sclerosis and Crohn's disease patients; suggesting that the encoded protein may play a role in autoimmune disease. Additionally; this protease may play a role in viral infection through its cleavage of ACE2; the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq; Aug 2020]

Shipping Conditions:: Ambient