Human NPY Protein; hFc Tag

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£189.00

SKU:: PME101455
Additional Names:: PYY4
Molecular Weight:: The protein has a predicted molecular mass of 34.2 kDa after removal of the signal peptide. The apparent molecular mass of NPY-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: NPY
NPY(Tyr29-Trp97) hFc(Glu99-Ala330):: NPY(Tyr29-Trp97) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes; including cortical excitability; stress response; food intake; circadian rhythms; and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase; activate mitogen-activated protein kinase (MAPK); regulate intracellular calcium levels; and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels; higher alcohol consumption; and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq; Oct 2014]

Shipping Conditions:: Ambient