Human TTR Protein; hFc Tag

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£189.00

SKU:: PME101430
Additional Names:: CTS; TTN; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651
Molecular Weight:: The protein has a predicted molecular mass of 39.9 kDa after removal of the signal peptide. The apparent molecular mass of TTR-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: TTR
TTR(Gly21-Glu147) hFc(Glu99-Ala330):: TTR(Gly21-Glu147) hFc(Glu99-Ala330)
Extra Details:: This gene encodes one of the three prealbumins; which include alpha-1-antitrypsin; transthyretin and orosomucoid. The encoded protein; transthyretin; is a homo-tetrameric carrier protein; which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis; nerve regeneration; autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition; predominantly affecting peripheral nerves or the heart; while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases; including amyloidotic polyneuropathy; euthyroid hyperthyroxinaemia; amyloidotic vitreous opacities; cardiomyopathy; oculoleptomeningeal amyloidosis; meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq; Aug 2017]

Shipping Conditions:: Ambient