Human CRTH2 Protein; hFc Tag

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£189.00

SKU:: PME101428
Additional Names:: DP2; DL1R; CD294; CRTH2; GPR44
Molecular Weight:: The protein has a predicted molecular mass of 29.9 kDa after removal of the signal peptide. The apparent molecular mass of CRTH2-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: CRTH2
CRTH2(Met1-His33) hFc(Glu99-Ala330):: CRTH2(Met1-His33) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils; basophils; and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq; Mar 2011]