Human CXCR6 Protein; hFc Tag

Size

£189.00

SKU:: PME101427
Additional Names:: BONZO; CD186; CDw186; STRL33; TYMSTR
Molecular Weight:: The protein has a predicted molecular mass of 30.0 kDa after removal of the signal peptide. The apparent molecular mass of CXCR6-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: CXCR6
CXCR6(Met1-Val32) hFc(Glu99-Ala330):: CXCR6(Met1-Val32) hFc(Glu99-Ala330)
Extra Details:: The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1; CXCR2; CXCR3; CXCR4; CXCR5; and CXCR7. This gene; which maps to the chemokine receptor gene cluster; is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand; chemokine ligand 16 (CCL16); are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver; spleen red pulp; intestine; lungs; and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes; which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells; in conjunction with CD4. [provided by RefSeq; Aug 2020]

Shipping Conditions:: Ambient