Human CCL5 Protein; hFc Tag

Size

£178.00

SKU:: PME101421
Additional Names:: SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
Molecular Weight:: The protein has a predicted molecular mass of 34.0 kDa after removal of the signal peptide. The apparent molecular mass of CCL5-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Target:: CCL5
CCL5(Ser24-Ser91) hFc(Glu99-Ala330):: CCL5(Ser24-Ser91) hFc(Glu99-Ala330)
Extra Details:: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine; a member of the CC subfamily; functions as a chemoattractant for blood monocytes; memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5); and it suppresses in vitro replication of the R5 strains of HIV-1; which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq; Jul 2013]

Shipping Conditions:: Ambient