Human LEP Protein; hFc Tag

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£174.00

SKU:: PME101417
Additional Names:: OB; OBS; LEPD
Molecular Weight:: The protein has a predicted molecular mass of 42.2 kDa after removal of the signal peptide. The apparent molecular mass of LEP-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Target:: LEP
LEP(Val22-Cys167) hFc(Glu99-Ala330):: LEP(Val22-Cys167) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain; which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions; and is involved in the regulation of immune and inflammatory responses; hematopoiesis; angiogenesis; reproduction; bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq; Aug 2017]

Shipping Conditions:: Ambient