Human RAMP1 Protein; mFc Tag

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£178.00

SKU:: PME101377
Additional Names:: RAMP1
Molecular Weight:: The protein has a predicted molecular mass of 36.7 kDa after removal of the signal peptide. The apparent molecular mass of RAMP1-mFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Target:: RAMP1
RAMP1(Cys27-Ser117) mFc(Pro99-Lys330):: RAMP1(Cys27-Ser117) mFc(Pro99-Lys330)
Extra Details:: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins; called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR; a receptor with seven transmembrane domains; can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor; depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein; CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation; maturation; and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq; Apr 2015]

Shipping Conditions:: Ambient