PME101356
Human MICAa3 Protein; mFc Tag
Size
£169.00
- SKU:
- PME101356
- Additional Names:
- MICA;MIC-A;PERB11.1
- Molecular Weight:
- The protein has a predicted molecular mass of 37.9 kDa after removal of the signal peptide. The apparent molecular mass of MICAa3(203-306)-mFc is approximately 35-70 kDa due to glycosylation.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- MICAa3
- MICAa3(Arg203-His306) mFc(Pro99-Lys330):
- MICAa3(Arg203-His306) mFc(Pro99-Lys330)
- Extra Details:
- This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface; although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis; and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq; Jan 2014]
- Shipping Conditions:
- Ambient