PME101338
Human MSR1 Protein; His Tag
Size
£169.00
- SKU:
- PME101338
- Additional Names:
- SRA;SR-A;CD204;SR-AI;phSR1;phSR2;SCARA1;SR-AII;SR-AIII
- Molecular Weight:
- The protein has a predicted molecular mass of 42.1 kDa after removal of the signal peptide.
- Purity:
- The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- MSR1
- 6×His tag MSR1(Lys77-Leu451):
- 6×His tag MSR1(Lys77-Leu451)
- Extra Details:
- This gene encodes the class A macrophage scavenger receptors; which include three different types (1; 2; 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis; Alzheimer's disease; and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum; making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed; indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq; Jul 2008]
- Shipping Conditions:
- Ambient