Human IL4 Protein; mFc Tag

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£169.00

SKU:: PME101307
Additional Names:: BSF1;BCGF1;BSF-1;BCGF-1;IL-4
Molecular Weight:: The protein has a predicted molecular mass of 41.2 kDa after removal of the signal peptide. The apparent molecular mass of IL4-mFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: IL4
IL4(His25-Ser153) mFc(Pro99-Lys330):: IL4(His25-Ser153) mFc(Pro99-Lys330)
Extra Details:: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13; which may contribute to many overlapping functions of this cytokine and IL13. STAT6; a signal transducer and activator of transcription; has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene; IL3; IL5; IL13; and CSF2 form a cytokine gene cluster on chromosome 5q; with this gene particularly close to IL13. This gene; IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair; counterbalancing the effects of proinflammatory type 1 cytokines; however; it also promotes allergic airway inflammation. Moreover; IL-4; a type 2 cytokine; mediates and regulates a variety of human host responses such as allergic; anti-parasitic; wound healing; and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response; IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients; but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq; Aug 2020]

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