Human ARTN Protein; hFc Tag

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£174.00

SKU:: PME101295
Additional Names:: ART;EVN;NBN;ENOVIN
Molecular Weight:: The protein has a predicted molecular mass of 38.1 kDa after removal of the signal peptide. The apparent molecular mass of ARTN-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: ARTN
ARTN(Ala108-Gly220) hFc(Glu99-Ala330):: ARTN(Ala108-Gly220) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor; and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth; metastasis; and drug resistance in mammary carcinoma. [provided by RefSeq; Aug 2016]

Shipping Conditions:: Ambient