Human LY6H Protein; hFc Tag

Size

£178.00

SKU:: PME101251
Additional Names:: NMLY6
Molecular Weight:: The protein has a predicted molecular mass of 36.0 kDa after removal of the signal peptide. The apparent molecular mass of LY6H-hFc is approximately 35-55 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: LY6H
LY6H(Leu26-Gly115) hFc(Glu99-Ala330):: LY6H(Leu26-Gly115) hFc(Glu99-Ala330)
Extra Details:: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons.[UniProtKB/Swiss-Prot Function]