Human ACVRL1 Protein; hFc Tag

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£169.00

SKU:: PME101234
Additional Names:: ACVRLK1;ALK-1;ALK1;HHT;HHT2;ORW2;SKR3;TSR-I
Molecular Weight:: The protein has a predicted molecular mass of 36.8 kDa after removal of the signal peptide. The apparent molecular mass of ACVRL1-hFc is approximately 35-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: ACVRL1
ACVRL1(Asp22-Gln118) hFc(Glu99-Ala330):: ACVRL1(Asp22-Gln118) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains; a glycine- and serine-rich region (called the GS domain) preceding the kinase domain; and a short C-terminal tail. The encoded protein; sometimes termed ALK1; shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2; also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq; Jul 2008]

Shipping Conditions:: Ambient