Human ACVR1C Protein; hFc Tag

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£169.00

SKU:: PME101233
Additional Names:: ACVRLK7;ALK7
Molecular Weight:: The protein has a predicted molecular mass of 36.0 kDa after removal of the signal peptide. The apparent molecular mass of ACVR1C-hFc is approximately 35-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: ACVR1C
ACVR1C(Leu22-Glu113) hFc(Glu99-Ala330):: ACVR1C(Leu22-Glu113) hFc(Glu99-Ala330)
Extra Details:: ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding; type I receptors phosphorylate cytoplasmic SMAD transcription factors; which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al.; 2001 [PubMed 12063393]).[supplied by OMIM; Mar 2008]