Human VPS4 Protein; His Tag

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£174.00

SKU:: PME101167
Additional Names:: CIMDAG;SKD1;SKD1A;SKD2;VPS4A;VPS4-1
Molecular Weight:: The protein has a predicted molecular mass of 49.7 kDa after removal of the signal peptide. The apparent molecular mass of VPS4-His is approximately 55-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: VPS4
VPS4(Met1-Ser437) 6×His tag:: VPS4(Met1-Ser437) 6×His tag
Extra Details:: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities); and is the homolog of the yeast Vps4 protein. In humans; two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other; and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments; and are involved in intracellular protein trafficking; similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq; Jul 2008]

Shipping Conditions:: Ambient