Human NLRP3 Protein; Flag Tag

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£219.00

SKU:: PME101158
Additional Names:: AGTAVPRL;AII;AVP;C1orf7;CIAS1;CLR1.1;DFNA34;FCAS;FCAS1;FCU;KEFH;MWS;NALP3;PYPAF1
Molecular Weight:: The protein has a predicted molecular mass of 121.8 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: NLRP3
NLRP3(Lys2-Trp1036) Flag:: NLRP3(Lys2-Trp1036) Flag
Extra Details:: This gene encodes a pyrin-like protein containing a pyrin domain; a nucleotide-binding site (NBS) domain; and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC; which contains a caspase recruitment domain; and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling; and it plays a role in the regulation of inflammation; the immune response; and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS); Muckle-Wells syndrome (MWS); chronic infantile neurological cutaneous and articular (CINCA) syndrome; and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however; insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq; Oct 2008]

Shipping Conditions:: Ambient