Human AREG Protein; hFc Tag

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£202.00

SKU:: PME101132
Additional Names:: AR;CRDGF;AREGB;SDGF
Molecular Weight:: The protein has a predicted molecular mass of 44.9 kDa after removal of the signal peptide. The apparent molecular mass of AREG-hFc is approximately 53-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: AREG
AREG(Ser20-Lys187) hFc(Glu99-Ala330):: AREG(Ser20-Lys187) hFc(Glu99-Ala330)
Extra Details:: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes; Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells; and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland; oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype; and is also associated with other pathological disorders; including various types of cancers and inflammatory conditions. [provided by RefSeq; Apr 2014]

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