PME101129
Human CD59 Protein; hFc Tag
Size
£202.00
- SKU:
- PME101129
- Additional Names:
- HRF20;MAC-IP;MACIF;MIRL;MIC11;MIN1;MIN2;MIN3;MSK21
- Molecular Weight:
- The protein has a predicted molecular mass of 35.1 kDa after removal of the signal peptide. The apparent molecular mass of CD59-hFc is approximately 40-53 kDa due to glycosylation.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- CD59
- CD59(Leu26-Asn102) hFc(Glu99-Ala330):
- CD59(Leu26-Asn102) hFc(Glu99-Ala330)
- Extra Details:
- This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis; and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex; whereby it binds complement C8 and/or C9 during the assembly of this complex; thereby inhibiting the incorporation of multiple copies of C9 into the complex; which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency; a disease resulting in hemolytic anemia and thrombosis; and which causes cerebral infarction. Multiple alternatively spliced transcript variants; which encode the same protein; have been identified for this gene. [provided by RefSeq; Jul 2008]
- Shipping Conditions:
- Ambient