PME101124
Human NPR1 Protein; hFc Tag
Size
£224.00
- SKU:
- PME101124
- Additional Names:
- ANP-A;ANPR-A;ANPRA;NPR-A;GC-A
- Molecular Weight:
- The protein has a predicted molecular mass of 75.0 kDa after removal of the signal peptide. The apparent molecular mass of NPR1-hFc is approximately 95-130 kDa due to glycosylation.
- Purity:
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- DIMA Biotechnology Ltd
- Formulation:
- Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
- Target:
- NPR1
- NPR1(Gly33-Glu473) hFc(Glu99-Ala330):
- NPR1(Gly33-Glu473) hFc(Glu99-Ala330)
- Extra Details:
- Guanylyl cyclases; catalyzing the production of cGMP from GTP; are classified as soluble and membrane forms (Garbers and Lowe; 1994 [PubMed 7982997]). The membrane guanylyl cyclases; often termed guanylyl cyclases A through F; form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain; a single membrane-spanning domain; and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962); which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295); respectively).[supplied by OMIM; May 2009]
- Shipping Conditions:
- Ambient