Human TNFRSF1A Protein; hFc Tag

Size

£171.00

SKU:: PME101025
Additional Names:: Tumor necrosis factor receptor superfamily member 1A;TNF-R1;TNF-RI;TNFR-I
Molecular Weight:: The protein has a predicted molecular mass of 46.6 kDa after removal of the signal peptide. The apparent molecular mass of TNFRSF1A-hFc is approximately 55-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: TNFRSF1A
TNFRSF1A(Leu30-Thr211) hFc(Glu99-Ala330):: TNFRSF1A(Leu30-Thr211) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms; respectively; of its ligand; tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation; which plays a role in cell survival; apoptosis; and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor; which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS); characterized by fever; abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq; Sep 2016]

Shipping Conditions:: Ambient