Human TGFBR2 Protein; hFc Tag

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£171.00

SKU:: PME101017
Additional Names:: AAT3;FAA3;LDS1B;LDS2;LDS2B;MFS2;RIIC;TAAD2;TBR-ii;TBRII;TGFbeta-RII;TGFR-2
Molecular Weight:: The protein has a predicted molecular mass of 41.6 kDa after removal of the signal peptide. The apparent molecular mass of TGFBR2-hFc is approximately 55-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: TGFBR2
TGFBR2(Thr23-Asp159) hFc(Glu99-Ala330):: TGFBR2(Thr23-Asp159) hFc(Glu99-Ala330)
Extra Details:: The protein encoded by this gene is a transmembrane protein that has a protein kinase domain; forms a heterodimeric complex with TGF-beta receptor type-1; and binds TGF-beta. This receptor/ligand complex phosphorylates proteins; which then enter the nucleus and regulate the transcription of genes related to cell proliferation; cell cycle arrest; wound healing; immunosuppression; and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome; Loeys-Deitz Aortic Aneurysm Syndrome; and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq; Aug 2017]

Shipping Conditions:: Ambient