Human MMP2 Protein; His Tag

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£219.00

SKU:: PME100981
Additional Names:: CLG4;CLG4A;MMP-2;MMP-II;MONA;TBE-1
Molecular Weight:: The protein has a predicted molecular mass of 71.8 kDa after removal of the signal peptide.The apparent molecular mass of MMP2-His is approximately 55-70 kDa due to glycosylation.
Purity:: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: MMP2
MMP2(Ala30-Cys660) 6×His tag:: MMP2(Ala30-Cys660) 6×His tag
Extra Details:: This gene is a member of the matrix metalloproteinase (MMP) gene family; that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A; type IV collagenase; that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members; activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases; or; intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system; endometrial menstrual breakdown; regulation of vascularization; and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq; Oct 2014]

Shipping Conditions:: Ambient