Human ERG Protein; hFc Tag

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£171.00

SKU:: PME100943
Additional Names:: erg-3;p55
Molecular Weight:: The protein has a predicted molecular mass of 49.39 kDa after removal of the signal peptide.
Purity:: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Storage Conditions:: Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Supplier:: DIMA Biotechnology Ltd
Formulation:: Lyophilized from sterile PBS; pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Target:: ERG
ERG(Val280-Glu405) hFc(Glu99-Ala330):: ERG(Val280-Glu405) hFc(Glu99-Ala330)
Extra Details:: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development; cell proliferation; differentiation; angiogenesis; inflammation; and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium; inducing vascular cell remodeling. It also regulates hematopoesis; and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations; resulting in different fusion gene products; such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer; EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported; but the full-length nature of many of these variants has not been determined. [provided by RefSeq; Apr 2014]

Shipping Conditions:: Ambient